If you are craving a hearty, comforting dish that brings together bold southwestern flavors with a rich, cheesy crust, then the John Wayne Casserole Recipe is exactly what you need. This beloved casserole combines seasoned ground beef, tangy tomatoes with green chilies, and a luscious cheese and sour cream layer all nestled on a buttery Bisquick biscuit crust. It’s the perfect meal to gather friends and family around the table, delivering warmth, satisfaction, and a little kick of spice that makes every bite unforgettable. Once you try this classic recipe, it’s sure to become a go-to favorite in your kitchen.

Ingredients You’ll Need
Every ingredient in this John Wayne Casserole Recipe is simple yet essential, working together to create a dish packed with flavor, texture, and color. From savory ground beef to creamy cheeses and the zesty bite of chilies, each component plays its part perfectly.
- 1 pound ground beef: Provides the savory, meaty base full of rich flavor.
- 1 packet taco seasoning mix: Adds a punch of authentic southwestern spices.
- 1/2 cup water: Helps the taco seasoning blend into the beef for maximum flavor absorption.
- 1 can (10 oz) diced tomatoes with green chilies, drained: Brings juiciness and a mild spicy tang.
- 1 can (4 oz) diced green chilies: Offers extra heat and texture contrast.
- 1 medium onion, chopped: Adds sweetness and a bit of bite when sautéed with the beef.
- 1/2 cup sour cream: Creates a creamy, cooling layer that balances the spices.
- 1/2 cup mayonnaise: Enhances richness and helps bind the cheese mixture.
- 1 cup shredded cheddar cheese (divided): Contributes sharp, tangy cheesiness.
- 1 cup shredded Monterey Jack cheese (divided): Adds a smooth, mellow meltiness.
- 2 cups Bisquick baking mix: Forms the easy and flaky biscuit crust that holds everything together.
- 1/2 cup water (for biscuit base): Moistens the Bisquick to create the perfect dough.
- 1/2 teaspoon garlic powder: Gives a subtle aromatic depth throughout the casserole.
- 1/2 teaspoon salt: Enhances all the savory flavors.
How to Make John Wayne Casserole Recipe
Step 1: Preparing the Beef Mixture
Start by preheating your oven to 350 degrees Fahrenheit for the perfect baking environment. While that warms up, cook the ground beef and chopped onion together in a skillet over medium heat until the beef is browned and fully cooked. Don’t forget to drain any excess grease to keep the casserole from getting too oily. Once the meat is ready, stir in the taco seasoning packet and half a cup of water. Let this simmer gently for two to three minutes so the vibrant spices can infuse every bite of meat.
Step 2: Making the Biscuit Crust
While the beef is simmering, mix the Bisquick with half a cup of water in a bowl until it forms a soft dough. This biscuit base is surprisingly simple but critical because it adds light, flaky texture to your casserole’s foundation. Press this dough evenly into a greased 9×13-inch baking dish, making sure it reaches all corners to form a sturdy crust layer that will support the filling beautifully.
Step 3: Assembling Layers
Spread the cooked beef and onion mixture evenly over your biscuit base – this lets the savory and spicy flavors soak into the crust while baking. Next, in a separate bowl, combine the sour cream, mayonnaise, half of the shredded cheddar and Monterey Jack cheeses, and the garlic powder. Mix well, then gently spread this creamy, cheesy topping over the beef layer. This layer creates a luscious contrast that ties all the flavors together.
Step 4: Adding the Final Touches
Next up, evenly spread the drained diced tomatoes with green chilies and the additional can of diced green chilies on top of the creamy cheese mixture. These add bursts of tanginess and heat that wake up your taste buds. Finally, sprinkle the remaining cheddar and Monterey Jack cheeses over everything. This final cheesy cap melts into a bubbly, golden delight during baking.
Step 5: Baking to Perfection
Place your casserole in the oven and bake uncovered for 30 to 35 minutes. You want to bake until the cheese is melted and bubbling, and the crust is cooked through and turning golden brown. Give it a few minutes to rest out of the oven before serving so the layers can settle and slice beautifully.
How to Serve John Wayne Casserole Recipe

Garnishes
A great garnish can elevate your John Wayne Casserole Recipe instantly. Fresh cilantro leaves or chopped green onions sprinkled on top add a bright, herbaceous note. If you like a bit of creaminess, dollops of extra sour cream or guacamole on the side make excellent accompaniments. A squeeze of fresh lime juice right before serving can also brighten the flavors wonderfully.
Side Dishes
This casserole stands out perfectly alongside simple sides. A crisp green salad with a light vinaigrette balances the richness, while buttery corn or seasoned black beans complement the southwestern flavors beautifully. If you want to keep it classic, chips and salsa are always a crowd-pleaser with this dish.
Creative Ways to Present
For a fun presentation, serve John Wayne Casserole Recipe in individual ramekins or mini cast-iron skillets at a party or family gathering. Layer with a colorful salad on the side for a vibrant plate, or top with sliced jalapeños and fresh avocado for a guest-ready meal that looks as good as it tastes. Using a wooden board for a rustic vibe also adds a warm, inviting touch at your table.
Make Ahead and Storage
Storing Leftovers
You can prepare the John Wayne Casserole Recipe ahead of time by assembling everything in the baking dish, covering it tightly, and refrigerating for up to two days before baking. Once cooked, leftovers should be stored in an airtight container in the fridge and enjoyed within 3 to 4 days to keep the flavors fresh and the texture intact.
Freezing
This casserole freezes beautifully if you want to save portions for busy days. Wrap it well with plastic wrap and aluminum foil or place individual portions in freezer-safe containers. It will keep well for up to three months. When you’re ready, thaw overnight in the fridge before reheating.
Reheating
Reheat leftovers in the oven at 350 degrees Fahrenheit for about 15-20 minutes or until heated through and the cheese is bubbling again. For quicker reheating, microwave individual servings for 1 to 2 minutes, but the oven method helps maintain that crisp biscuit crust and melts the cheese perfectly.
FAQs
Can I make the John Wayne Casserole Recipe spicier?
Absolutely! You can add sliced jalapeños, a dash of hot sauce, or swap the mild green chilies for a hotter variety to ramp up the spice level to your liking.
Is there a way to make this casserole gluten-free?
Yes, substitute the Bisquick with a gluten-free baking mix available at most stores. Just make sure the seasoning mix is also gluten-free for a safe swap.
Can I use ground turkey instead of ground beef?
Definitely! Ground turkey works well and will make the dish a bit leaner, though you might want to add a touch more seasoning to keep the flavors bold.
How can I make the casserole creamier?
Increase the amount of sour cream to 3/4 cup or add a bit of cream cheese to the mixture for an even richer, creamier texture.
Can this recipe be doubled?
Yes, you can easily double the ingredients and use a larger baking dish. Just watch the baking time, as it might need a bit longer to cook through evenly.
Final Thoughts
This John Wayne Casserole Recipe is a fantastic blend of comfort and zest that really stands out on any weeknight dinner table. The layers of seasoned beef, tangy chilies, and melty cheese atop a biscuit crust make for a dish that’s satisfying in every bite. I can’t recommend it enough as a family-friendly meal that’s easy to prepare but feels like a special occasion. Give it a try and watch how quickly it disappears!
Print
John Wayne Casserole Recipe
- Prep Time: 20 minutes
- Cook Time: 35 minutes
- Total Time: 55 minutes
- Yield: 8 servings
- Category: Main Course
- Method: Baking
- Cuisine: American
Description
John Wayne Casserole is a hearty American main course featuring seasoned ground beef layered over a biscuit crust, topped with a creamy cheese mixture, tomatoes, green chilies, and melted cheddar and Monterey Jack cheeses. This comforting casserole is baked to golden perfection, making it a perfect dish for family dinners or gatherings.
Ingredients
Meat Mixture
- 1 pound ground beef
- 1 packet taco seasoning mix
- 1/2 cup water
- 1 can (10 oz) diced tomatoes with green chilies, drained
- 1 can (4 oz) diced green chilies
- 1 medium onion, chopped
Cheese Mixture
- 1/2 cup sour cream
- 1/2 cup mayonnaise
- 1/2 cup shredded cheddar cheese
- 1/2 cup shredded Monterey Jack cheese
- 1/2 teaspoon garlic powder
Biscuit Base
- 2 cups Bisquick baking mix
- 1/2 cup water
- 1/2 teaspoon salt
Toppings
- 1/2 cup shredded cheddar cheese (remaining)
- 1/2 cup shredded Monterey Jack cheese (remaining)
Instructions
- Preheat Oven: Set the oven to 350°F (175°C) to ensure it reaches the desired temperature while you prepare the casserole.
- Cook Ground Beef and Onion: In a skillet over medium heat, cook the ground beef with chopped onion until the beef is browned and cooked through. Drain any excess grease to keep the casserole from being greasy.
- Season Meat: Stir in the taco seasoning mix and 1/2 cup water into the beef and onion mixture. Simmer for 2-3 minutes to blend the flavors well.
- Prepare Biscuit Dough: In a bowl, combine the Bisquick baking mix, 1/2 teaspoon salt, and 1/2 cup water to form a dough. Press this dough evenly into the bottom of a greased 9×13-inch baking dish to create the biscuit crust base.
- Layer Meat Mixture: Spread the cooked and seasoned ground beef evenly over the biscuit base in the baking dish.
- Mix Cheese Spread: In another bowl, combine sour cream, mayonnaise, half of both the shredded cheddar and Monterey Jack cheeses, and garlic powder. Mix thoroughly.
- Apply Cheese Mixture: Spread the sour cream and cheese mixture over the beef layer evenly.
- Add Chilies and Tomatoes: Spoon the drained diced tomatoes with green chilies and diced green chilies on top of the cheese spread and distribute evenly.
- Top with Remaining Cheese: Sprinkle the remaining shredded cheddar and Monterey Jack cheeses evenly over the top of the casserole.
- Bake: Place the casserole uncovered in the preheated oven and bake for 30–35 minutes or until the cheese is melted, bubbly, and the biscuit crust is cooked through and golden.
- Rest: Remove the casserole from the oven and let it rest for 5–10 minutes before serving to allow it to set and cool slightly.
Notes
- This casserole can be prepared a day or two in advance; store it covered in the refrigerator and bake just before serving.
- For extra heat, add sliced jalapeños or a few dashes of hot sauce to the beef mixture.
- Serve with a crisp side salad or buttered corn for a complete meal.

